Keep appliance away from heat, which may cause deformation and poor fit
Only rinse with cold or room temperature water
Do not leave in the car during warm times of year
Keep appliance away from pets - they are expensive chew toys!
Use a cleaning solution/tabs like Denta Soak, Insta Fresh, or Retainer Brite
If any debris builds up on the appliance, it can be soaked in white vinegar for 30 minutes to an hour, just make sure to rinse it well before next use. Can also lightly brush away with a new toothbrush (toothpaste residue will make appliance appear cloudy)
Take out dentures nightly and allow to soak in water overnight
Use denture cleaner tabs like Polident or Efferdent